(Research Triangle Park, N.C.) Metabolon, Inc., the leader in metabolomics, biomarker discovery and biochemical analysis, announced today the publication of “Toxicogenomics and Metabolomics of Pentamethylchromanol (PMCol)-Induced Hepatotoxicity” in the journal Toxicological Sciences. The study was conducted by the Biosciences Division of SRI International in conjunction with Metabolon scientists. The study integrated classical toxicology, toxicogenomics, and metabolomic approaches to determine the mechanism of toxicity and identify sensitive early markers of target organ injury by PMCol. (more…)

(Research Triangle Park, N.C.) Metabolon, Inc., the leader in metabolomics, biomarker discovery and biochemical analysis, has announced the publication of “Metabolomics Revealed Elevated Macromolecular Degradation in Periodontal Disease,” in the Journal of Dental Research. Non-targeted biochemical profiling (metabolomics) provided insight into the biochemical mechanisms underlying periodontitis pathogenesis and identified potential disease biomarkers. The study was carried out by Virginia M. Barnes and colleagues of Colgate-Palmolive, and SUNY-Buffalo, School of Dental Medicine, with co-authors from Metabolon. Periodontal disease, described as inflammation of the gums, is among the most common infectious diseases. (more…)

(Research Triangle Park, N.C.) Metabolon, Inc., the leader in metabolomics, biomarker discovery and biochemical analysis, announced that they will give three presentations representing the company’s research into biomarkers at the European Association for the Study of Diabetes (EASD) Meeting in Lisbon, Portugal, September 12-18. Also presenting the EASD’s 43rd Claude Bernard keynote lecture is Metabolon collaborator, Ele Ferrannini, M.D., Professor of Medicine, University of Pisa, Italy, on Friday, September 16th. The lecture is from 1:00 p.m.-2:00 p.m. and is entitled “Diabetes: Brief History of a Conspiracy.” (more…)

(Research Triangle Park, N.C.) Metabolon, Inc., the leader in metabolomics, biomarker discovery and biochemical analysis, announced today the publication of “Dietary Leucine - An Environmental Modifier of Insulin Resistance Acting on Multiple Levels of Metabolism” in PLoS One (PLoS ONE 6(6): e21187.doi:10.1371/journal.pone. 0021187). Non-targeted biochemical profiling (metabolomics) provided insight into the biochemical mechanisms of leucine’s effects on metabolism. The study was carried out by lead investigator C. Ron Kahn, M.D. and colleagues at the Joslin Diabetes Center and Harvard Medical School and Metabolon. (more…)

(Research Triangle Park, N.C.) Metabolon, Inc., the leader in metabolomics, biomarker discovery and biochemical analysis, announced today that it is now offering a tandem mass spectrometry (LC/MS/MS) test for detection of Vitamin D deficiency. The test is being run in Metabolon’s high-complexity CLIA registered laboratory in Research Triangle Park, NC. This test is available for patient testing. (more…)

(Research Triangle Park, N.C.) Metabolon, Inc., the leader in metabolomics, biomarker discovery and biochemical analysis, announced today that two posters highlighting the Company’s research into insulin resistance biomarkers will be presented at the American Diabetes Association Meeting in San Diego, June 24-28. The posters demonstrate how insulin resistance markers can be utilized in identifying people at high risk for developing type 2 diabetes or fatty liver disease. (more…)

(Research Triangle Park, N.C.) Metabolon, Inc., the leader in metabolomics, biomarker discovery and analysis, announces the publication of “Metabolomics Analysis Reveals Elevation of 3-Indoxyl Sulfate in Plasma and Brain during Chemically-induced Acute Kidney Injury in Mice: Investigation of Nicotinic Acid Receptor Agonists” in Toxicology and Applied Pharmacology (doi: 10.1016/j.taap.2011.05.015). The study was authored by Dr. Joanna R. Zgoda-Pols and colleagues at Merck Research Laboratories in New Jersey and scientists at Metabolon. (more…)

(Research Triangle Park, N.C.) NCTechNews, North Carolina’s technology news source, will be blogging live from the BIO International Convention in Washington, D.C. June 27-30 to cover major trends affecting the life sciences community. The BIO International Convention is the largest global event of its kind, attracting the biggest names in biotech and featuring keynotes and sessions from key policymakers, scientists, CEOs, and celebrities, and the world’s largest biotechnology exhibition - the BIO Exhibition. (more…)

(Research Triangle Park, N.C.) Metabolon, Inc., the leader in metabolomics, biomarker discovery and biochemical analysis, announces the publication of “A Sister Group Contrast Using Untargeted Global Metabolomic Analysis Delineates the Biochemical Regulation Underlying Desiccation Tolerance in Sporobolus stapfianus” in The Plant Cell Online (April 2011, tpc.110.082800). Non-targeted biochemical profiling (metabolomics) provided insight into the biochemical mechanisms underlying plant drought tolerance. The study was carried out by Dr. Melvin J. Oliver and colleagues, USDA-ARS scientists at the University of Missouri in Columbia, Dr. Bernard W.M. Wone and John C. Cushman and colleagues at the University of Nevada in Reno, and Dr. John Ryals, Dr. Lining Guo, and Dr. Danny Alexander at Metabolon, Inc. (more…)

(Research Triangle Park, N.C.) Metabolon, Inc., the leader in metabolomics, biomarker discovery and analysis, announces the publication of “Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome”, in The Proceedings of the National Academy of Sciences (PNAS 108 (8) 3270-3275). Application of non-targeted biochemical profiling (metabolomics) to mutant IDH1- and IDH2-expressing human oligodendroglioma (HOG) cells revealed altered metabolism in the cells and provided clues to the pathogenesis of tumors with IDH1 and IDH2 mutations. The study was performed by co-authors Hai Yan and colleagues from Duke University Medical Center and Bert Vogelstein and colleagues at Johns Hopkins University School of Medicine and the metabolomic profiling was carried out at Metabolon. (more…)

(Washington, D.C.) The Biotechnology Industry Organization (BIO) today announced the Business Roundtable series for the 13th Annual BIO CEO & Investor Conference – the world’s largest independent investor conference focused on publicly-traded biotechnology companies. This conference provides a forum for institutional investors, research analysts and senior industry executives to discuss investment trends, attend company presentations, conduct one-on-one meetings, and learn about investment opportunities within the biotechnology industry. (more…)

(Research Triangle Park, N.C.) Metabolon, Inc., leaders in global metabolomics, biomarker discovery and biochemical analysis, announces the publication of “Assessment of Dentifrice on Periodontal Disease Biomarkers in Gingival Crevicular Fluid”, in the Journal of Periodontology (2010, Vol. 81, No. 9, Pages 1273-1279). The article reports the results of a biomarker validation study carried out in collaboration with co-authors Virginia M. Barnes and colleagues of Colgate-Palmolive, a global leader in oral care. Periodontal disease, described as inflammation of the gums, is among the most common infectious diseases. Triclosan, the active ingredient in Colgate Total (CT), is a proven therapeutic agent against gingivitis. CT is the only FDA approved dentifrice for the treatment of gingivitis. (more…)